Increased pressure worries many, but it does not always work to find a really suitable therapeutic agent for its normalization. Hypertension is a disease that is spread all over the world and the number of people with this disease is increasing every year.
Many doctors recommend using noliprel with elevated pressure. This drug allows you to normalize the pressure in a short time. But before using it, you should carefully study the instructions, because this medicine has some contraindications.
Types, release form, composition
Noliprel is available in several varieties. Each species differs in the dosage level of the active ingredients. Each species has two main elements. The table below lists the varieties of this medication and the level of active ingredients.
| Drug name | The content of indapamide, in mg | The content of perindopril, in mg |
|---|---|---|
| Noliprel | 0,625 | 2 |
| Noliprel Forte | 1,25 | 4 |
| Noliprel A Bi-Forte | 2,5 | 10 |
| Noliprel a | 0,625 | 2,5 |
| Noliprel A Forte | 1,25 | 5 |
In the release forms with the prefix A, together with the active component perindopril, there is an amino acid arginine. This acid, together with its constituents, has a positive effect on heart activity.
All types of Noliprel are available in the form of tablets with an oblong shape or round. Tablets have a white structure, in the middle there is a separation risk.
In addition to the two active elements - indapamide and perindopril, there are other additional components. The main ones are magnesium stearate, silica in a colloidal anhydrous state, lactose monohydrate, maltodexin, macragol 6000, hypromellose and others.
Noliprel is available in plastic bottles or in carton packs. Available in 14, 29 and 30 pieces.
Indications and contraindications
It is recommended to use Noliprel tablets during the presence of high blood pressure. The active ingredients contained in this medicine contribute to the suppression of high blood pressure and quickly bring it back to normal.
It is often prescribed for essential hypertension, which is accompanied by a primary, pathological, pronounced increase in blood pressure.
Noliprel is prescribed as part of complex medical therapy for diabetes mellitus, symptomatic hypertension. The use of the drug during these ailments helps prevent the development of vascular complications in the kidneys.
But before you use this drug, do not forget that it has some contraindications for which it should not be used.
- the presence of hypersensitivity to the active components of the drug, as well as to ACE inhibitors, auxiliary components;
- should not be used for angioedema swelling of tissues, as well as in hereditary form. Especially if this type of edema manifested itself in the past;
- not recommended for use in hypokalemia. This condition is characterized by a reduced level of potassium ions in the blood;
- contraindicated in severe renal failure;
- during stenosis (narrowing) of the renal arteries in both kidneys;
- the presence of kidney failure in severe form;
- It should not be taken simultaneously with medicines that prolong the QT interval on the electrocardiogram. Also, do not use in conjunction with some antiarrhythmic drugs;
- when carrying a child;
- lactation.
With caution, the remedy should be taken in the presence of systemic pathological disorders in the connective tissue - scleroderma, lupus erythematosus.
It should also be used under constant control when used together with immunosuppressants, in violation of the blood red bone marrow, with a reduced volume of blood circulation, with angina, in the presence of cerebrovascular pathological processes, with sudden jumps in blood pressure, in case of heart failure in a chronic form, with sugar diabetes, after surgery for a kidney transplant.
They are used with caution by patients in old age over 65 years and by children and teenagers under 18 years of age. Before you apply, be sure to consult a doctor.
Noliprel: instructions for use for adults and children
Noliprel is recommended to be taken once a day. It is taken in the morning, preferably before eating. During the application of the tablet does not need to chew, break. To facilitate the reception of the pill you need to drink water.
With essential hypertension, diabetes mellitus per day, the average dosage of the medicine is one tablet, which must be taken once a day. For the elderly, as well as for patients with kidney failure, a lower dose is required.
Normally, Noriprel is prescribed in cases where single-component first-line drugs did not give positive results during treatment. In these cases, these types of funds are replaced by the drug Noriprel. The course of treatment should be determined only by the attending physician.
How to take during pregnancy and lactation
The drug Noliprel is not recommended for use in the period of carrying a child. If treatment using this medication was prescribed before pregnancy, then it is better to replace it with another medication that is allowed during pregnancy.
Even if it was taken in the first trimester of pregnancy, the constituent components will not affect the course of pregnancy and fetal development, but the features of its fetotoxic effect have not been studied.
This drug can not be used in the second and third trimester of pregnancy. Active elements may adversely affect the development of the child. Substances of the drug have a detrimental effect on the formation of the bones of the skull, adversely affect the functioning of the kidneys.
In the future, the child may develop arterial hypertension, and the development of renal failure is sometimes noted.
Noliprel is contraindicated in breastfeeding. The fact is that the components reduce the amount of breast milk and slow down its production. In addition, if this medicine is used during breastfeeding, jaundice and hypokalemia may occur in an infant.
If the use of this drug is vital for the mother, then for the period of its use it is worth refusing to breastfeed the child.
Side effects, overdose
The following side effects may occur during use of the drug Noliprel:
- On the part of the genitourinary system - in rare cases, there is a deterioration in the activity of the kidneys, potency may decrease. When using the drug in conjunction with other diuretics, an increase in the level of creatinine in the composition of urine and blood can be observed;
- From the heart and blood vessels. When using this medication may increase orthostatic collapse, sometimes there is increased hypotension. In rare cases, all these symptoms can lead to arrhythmias, myocardial infarction, stroke;
- Violations of the digestive system. Violations can manifest in the form of vomiting, nausea, abdominal pain, increased dryness of the mucous membrane of the throat. Sometimes there is bloating and constipation;
- On the part of the nervous system, frequent headaches may occur, which may additionally be accompanied by vertigo. Sometimes ringing in the ears, loss of appetite, the appearance of seizures;
- Sometimes there may be disorders of the respiratory system. At the same time, there may be a short-term dry cough, a runny nose, difficulty breathing, cramps in the lungs;
- The following phenomena can be observed in the circulatory system - the state of hyperglycemia, an increase in the level of urea, pancytopenia, thrombocytopenia and other phenomena;
- Skin rashes, urticaria symptoms, redness, itching and other allergic manifestations may appear on the skin.
When the dose is exceeded, it can manifest as a strong reduction in blood pressure, as well as cause a state of hypokalemia. In addition, overdose may experience the following effects:
- drowsiness;
- the state of anuria and polyuria;
- manifestation of nausea, which can lead to vomiting;
- decrease in heart rate level;
- fainting;
- the appearance of cold sweat with chills;
- muscle cramps;
- dizziness.
If you have symptoms of overdose, you must stop using the drug and consult your doctor.
Special instructions, drug interactions
Before using Noliprel, be sure to read the instructions for use, because this tool has special instructions that must be strictly followed.
- To reduce the likelihood of side effects, you need to start applying the medicine in the minimum effective dosage;
- It is necessary to use it only with the ineffectiveness of single-component medicines for lowering blood pressure;
- If surgery is required, the anesthesiologist must be warned that you are using Noliprel;
- For patients in old age over 65 years, it is necessary to reduce the dosage;
- If there is renal failure with moderate severity, then the dosage adjustment must be made;
- Since the tool is used for a long time, it is imperative to monitor the indicators of the functional activity of the liver, kidneys, red bone marrow;
- Do not use for children and adolescents under 18 years of age, pregnant women and during lactation;
- Since the drug reduces attention, mental activity should be for the period of treatment to refuse to perform activities that require increased attentiveness.
The combined use of pentamidine, vincamine, bepridil, erythromycin (for intravenous administration), sultoprid, halofantrin, antiarrhythmic drugs (hydroquinidine, quinidine, disopyramide, bretily, amiodarone, sotalol) can lead to Pirouette type arrhythmia.
Noliprel causes increased hypoglycemic effects of insulin and sulfonylurea derivatives.
Simultaneous use with Baclofen, tricyclic antidepressants and antipsychotics can lead to an increase in the hypotensive effect of Noliprel.
When used with nonsteroidal anti-inflammatory drugs can cause the appearance of acute renal failure.
When applying Noliprel with drugs that cause a decrease in potassium, hypokalemia may occur.
With simultaneous use with cardiac glycosides, it is necessary to take into account that with a reduced level of potassium, an increase in the toxic effects of cardiac glycosides may be observed.
Price of the drug, analogues
The average cost of the drug in pharmacies ranges from 590 to 730 rubles.
If necessary, this tool can be replaced with the following analogues:
- Amprilan - from 170 to 350 rubles;
- Berlipril - from 80 to 170 rubles;
- Accusid - from 400 to 500 rubles;
- Quinard - from 50 to 80 rubles;
- Liprasid - from 250 to 310 rubles;
- Perinev - 275 rubles;
- Diroton - 70-90 rubles;
- Renitek. The cost depends on the packaging, on average, the medicine costs from 70 to 250 rubles.
Reviews
When I started taking Noliprel, it helped me a lot, my pressure recovered, I began to feel much better. Against the background of this drug, I managed to even lose weight. However, after a certain period, I began to notice unpleasant symptoms in the form of persistent pain, dizziness. I had to go to the doctor. It turned out that the previous dose was calculated on my previous weight, and here I lost weight, that's why all these unpleasant effects appeared. The doctor corrected me the dosage and everything was fine.
Lyudmila, 48 years old, Kemerovo
I have been taking Noliprel in the morning for a long time, because during the day the pressure rises dramatically. I was prescribed by the attending physician. At first, when studying the instructions, I was frightened by a large list of side effects, but I still decided to start using it. Oddly enough, not a single symptom appeared to me. Now I additionally use Cardiomagnyl. Sharing these drugs stabilized my sleep, normalized blood pressure, and improved well-being.
Evgenia, 59 years old, St. Petersburg
A little more information about the drug Noliprel is in the next video.
